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Aging is Not a Disease, Damn It!

Discussion in 'The Cave' started by Dennis Clark, Sep 27, 2020.

  1. JanSz

    JanSz Gold

    I am interested in supplementing with melatonin.
    Need a suggested dose and timing for melatonin.
    -----------------------------------------------------------------
    Need a suggested dose and timing of serine.

    ..
    Jack said:
    If you want to try melatonin supplements,
    consider opting for serine instead of Melatonin.
    Why? It will create more DDW in her mitochondrial to improve Kreb’s bicycle.
    https://forum.jackkruse.com/index.p...ension-pvod-maybe-lymphoma.21395/#post-242132
    upload_2020-11-19_13-57-51.png
     
  2. Cocoa butter has been my go to for years https://shop.davidwolfe.com/product...ba-nacional-upper-amazonian-100-organic-12-oz
    As well as Tarrow https://www.whiteoakpastures.com/artisan/tallow/
     
  3. The precursors for melatonin are
    • tryptophan,
    • methionine,
    • inositol,
    • magnesium,
    • vitamins: B-2, B6 & D
    These can be taken anytime; however tryptophan can cause sleepiness. Your best magnesium is Magnesium L-Threonate because it can get passed your blood-brain-barrier.

    The aromatic tryptophan (Trp) and the non-aromatic methionine (Met) are often called amphipathic due to their ability to have both polar and non-polar character, because of their hydrophobic ring structure. They often are found at the surface of proteins or lipid membranes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262413/

    Serine (Ser) and threonine (Thr) are polar since both carry a hydroxyl group; thus they form hydrogen bonds as proton donors or acceptors.

    If you are interested in Serine - please consider: https://www.drbvitamins.com/products/phosphatidyl-serine-100mg
    It is phosphastidylserine which assists with the synthesis of trytophan https://pubmed.ncbi.nlm.nih.gov/10705462/

    Since the Liposome form of tryptophan is not commercially available yet, please consider taking phosphatidylcholine with it.
    https://www.vitacost.com/vitacost-synergy-phosphatidyl-choline
     
    Last edited: Nov 19, 2020
    JanSz likes this.
  4. JanSz

    JanSz Gold

  5. @JanSz - As you can tell @Jack Kruse in Ask Jack totally side stepped the question again - https://forum.jackkruse.com/index.p...als-secretion-of-melatonin.25345/#post-293388
    I thought I made it clear - I knew what I was talking about.
    We know the gut also produces melatonin -> that was not the question.
    I am not presenting questions that are linear (if-than-else). I'm asking for his hypothesis on how light-water-&-magnetism works.
    Thank you for listening,
    John
     
    JanSz likes this.
  6. Feedback -> What was not mentioned
    • GABA is a neurotransmitter and hormone. To make the hormone you must have: pyridoxyl-5-phosphate, zinc l-methionine and liposomal GABA <- These are your precursors for building your GABA neurotransmitters as well as hormone. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415746/
    • The inhibitor for GABA is Aspartic acid
    • Serotonin and Dopamine are very important in managing your GABA levels; Therefore - you must not take any form of Folic Acid.
    • Methylfolate (which is most often prescribed by NDs and Functional Clinicians) will stop the production of Melatonin, Dopamine & Norepinephrine
    • Any form of Folic Acid may help with depression; but not anxiety or fear https://www.jillcarnahan.com/2018/06/25/is-overmethylation-the-cause-of-your-anxiety/
    It is very important to understand that if your want Melatonin in your life. You must live without the supplementation of any form of folic acid !

    Reduced violent behavior following biochemical therapy http://www.hriptc.org/pdfs/Behavior paper - Elsiver - final 2.pdf

    I have no problem with the herbal recommendations in this NDs presentation; but "they" don't know why GABA is so "hard" to turn-on in their clients.
     
    Last edited: Nov 20, 2020
  7. Sue-UK

    Sue-UK Gold

    caroline and John Schumacher like this.
  8. Sue-UK

    Sue-UK Gold

    There's some gems about melatonin in this. https://jackkruse.com/tensegrity-5-magnetic-sense/ :)
     
    JanSz and John Schumacher like this.
  9. In the @Jack Kruse reference above, Jack presents the concept of increased magnetic flux during a decrease in light stimuli because he believed (during the writing) that: "Light photons un-condense the matter in us to release this energy in all matter. This is the basis of the photoelectric effect." This idea comes from studies like:
    However, these are based on an old static electrical model and imaginary mathematics to "support" the underlining idea.

    What we know from IEEE & plasma physics is that the photo-electrical phenomena is not static, even when we "currently" may not have the instrumentation for measuring it; though Ferromagnetic is a beginning to measuring it.

    Thus, when evaluating human cellular function, we must remember it is immersed in water; the electron and proton transduction over and through the human carbon molecules need to be modeled in a mechanism of action hypothesis with an understanding that capacitance is fractal in nature and is much more dynamic than previously thought. It is not that "Oxygen is the only gas that is naturally paramagnetic," as @Jack Kruse states. It is water's capacitance potential within our organelles, stimulated by the electromagnetic spectrum and its intensity that displaces a paramagnetic behavior. <- So what the hell does all the mean?

    Melatonin is a stimulus which rises both the magnetic and the proton-electron transport potential for our cells.

    The question is - Why does darkness stimulate the Pineal's secretion of melatonin? I do not believe it is the addition of static magnetic force during darkness, but the absence of light's stimuli. Yes -> the hypothalamus' role in sensing external temperature drop on the skin at night is also a stimulus which helps push the "ball" down the pathway. A fluctuation in magnetic potential is not stimulated by darkness.

    So we know
    • Melatonin is the hormone of darkness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334454/ -> The pineal gland receives input from postganglionic fibers, leading to the release of noradrenaline and increased production of cyclic AMP, thus activating the enzyme AANAT, mentioned above, which is critical to the production of melatonin.
    • The biomass precursors for building melatonin are
      • tryptophan,
      • methionine,
      • inositol,
      • magnesium,
      • vitamins: B-2, B6 & D
    • The inhibitor is any form of Folic Acid
     
    Last edited: Nov 21, 2020
    JanSz likes this.
  10. JanSz

    JanSz Gold

    Eat white chocolate, lose visceral fat.
    I am low on stearic acid anyhow.
    Thank you, Sue.
    My Fatty Acids analysis shows 15% deficiency of Stearic Acid, C18:0
    but the scale is rather happy with what I got.
    .
    upload_2020-11-21_11-48-19.png

    But whole-body fat not so much. Hopefully will get better with that white chocolate consumption.
    upload_2020-11-21_12-3-40.png

    upload_2020-11-21_11-41-44.png
     
    Last edited: Nov 21, 2020
  11. I emulsify it into my coffee
     
  12. Sue-UK

    Sue-UK Gold

    In Becker's book Cross Currents there is a discussion on the earth's rotation through the magnetosphere, and that any given spot on the earth's surface is in a constantly changing magnetic field. There's a diagram of the daily rise and fall in the strength of the magnetic field at one spot on the earth during a quiet period of solar activity. There's also a discussion on what is the magnetic organ, (separate from the pineal), but on the pineal, after acknowledging the retinal pathway, he says:

    "It appears that, over 2 billion years of evolution, living things have taken advantage of the two portions of the electromagnetic spectrum that could be depended upon to always be present: the geomagnetic field and visible light. In this view, it is no more surprising that life developed specific organs to sense the geomagnetic field and to derive timing information from it than that it developed specific organs to sense and derive information from light."

    "More recently, it has been shown that the pineal is also sensitive to the daily cyclic pattern in the Earth's magnetic field. Melatonin secretion in human subjects may be changed at will by exposure to steady magnetic fields of the same strength as the geomagnetic field. Apparently, nature determined that biological cycle activity was too important to be left to one environmental signal alone. "


    "Nature intended the pineal to simultaneously receive the same signals from the daily pattern of day-night and the same rise and fall in strength of the geomagnetic field. Obviously, when one or both signals are abnormal, the pineal does not respond in the normal fashion, and the body's biological cycles become disturbed - with important clinical consequences."

    The book Energy Medicine, the scientific basis, by James L Oschman, introduced me to the thalamic rhythm generator, as being another potential way to sense the geomagnetic field during the "free run period", so this study is interesting.
    https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-079X.2008.00628.x
    The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders
     
    Dan2 and John Schumacher like this.
  13. JanSz

    JanSz Gold

    https://forum.jackkruse.com/index.p...als-secretion-of-melatonin.25345/#post-293433
    ===============
    [QU OTE="John Schumacher, post: 293433, member: 23768"]For those following this thread:

    In the @Jack Kruse reference https://jackkruse.com/tensegrity-5-magnetic-sense/, Jack presents the concept of increased magnetic flux during a decrease in light stimuli because he believed (during the writing) that: "Light photons un-condense the matter in us to release this energy in all matter. This is the basis of the photoelectric effect." This idea comes from studies like:
    However, these are based on an old static electrical model and imaginary mathematics to "support" the underlining idea.

    What we know from IEEE & plasma physics is that the photo-electrical phenomena is not static, even when we "currently" may not have the instrumentation for measuring it; though Ferromagnetic is a beginning to measuring it.

    Thus, when evaluating human cellular function, we must remember it is immersed in water; the electron and proton transduction over and through the human carbon molecules need to be modeled in a mechanism of action hypothesis with an understanding that capacitance is fractal in nature and is much more dynamic than previously thought. It is not that "Oxygen is the only gas that is naturally paramagnetic," as @Jack Kruse states. It is water's capacitance potential within our organelles, stimulated by the electromagnetic spectrum and its intensity that displaces a paramagnetic behavior. <- So what the hell does all the mean?

    Melatonin is a stimulus which rises both the magnetic and the proton-electron transport potential for our cells.

    The question is - Why does darkness stimulate the Pineal's secretion of melatonin? I do not believe it is the addition of static magnetic force during darkness, but the absence of light's stimuli. Yes -> the hypothalamus' role in sensing external temperature drop on the skin at night is also a stimulus which helps push the "ball" down the pathway. A fluctuation in magnetic potential is not stimulated by darkness.

    So we know
    • Melatonin is the hormone of darkness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334454/ -> The pineal gland receives input from postganglionic fibers, leading to the release of noradrenaline and increased production of cyclic AMP, thus activating the enzyme AANAT, mentioned above, which is critical to the production of melatonin.



    • The biomass precursors for building melatonin are
      • tryptophan,
      • methionine,
      • inositol,
      • magnesium,
      • vitamins: B-2, B6 & D
    • The inhibitor is any form of Folic Acid

    [/QUOTE]
     
  14. JanSz

    JanSz Gold

    PhosphatidylSerine is only located in the inner mitochondrial membrane (true?)?
    I am using phosphatidylSerine (included in Doctor's Best Natural Brain Enhancers. (100mg/day)
    Recently added Now phosphatidylSerine 300mg/day
    I am using PhosphatidylCholine from BodyBio (1/day)

    My low level of melatonin (as shown below) includes supplementation as marked, which is (almost) all that you (kindly) suggested.
    At this time I want to add direct melatonin supplementation.
    Can't figure out the dose and timing.

    One of the research mention that rats were given it in the water (20mg/L melatonin).
    That looks like a very large dose. Say, if I would drink 2 liters of that kind of water it would be 40mg melatonin per day. (?????)


    upload_2020-11-21_18-19-43.png

    upload_2020-11-21_18-19-0.png
     
    Last edited: Nov 21, 2020
    John Schumacher likes this.
  15. JanSz

    JanSz Gold

    2013 January webinar (Mitochondrial Rx)
    ---------------------------------------
    From my notes, but this page does not exist at this time.
    http://www.jackkruse.com/forum/showthread.php?8785-Magnesium
    1. Key point before answer it........if you are dehydrated and loaded in an EMF environment Mg DOES NOTHING TO HELP YOU.
    2. Mg Threonate is best for neural issues........EMF is a neural issue because the brain has more mitochondria than any other organ by a long shot.
    3. orotate is best for the Heart.
    4. Malate is best for the muscles of the body
    5. Mg citrate is best for the gut
    6. When you take them only matters if you are also taking Vitamin D. Do not take Vitamin D with Mg......if you take D make sure your Mg is notwithin 2 hrs of the dose. Mg citrate be used round the clock with little issue.
     
    Last edited: Nov 21, 2020
    John Schumacher likes this.
  16. When supplementing with melatonin, please consider:
    I would titrate up, starting with one dose at 3pm, second after "dinner" (I eat before sunset) and a third before bed. Note: we will need to look at any contraindications with a dose of 9mg to 12mg per day.

    So far clinical studies come in for melatonin dosages at:
    General contraindications:
    • nifedipine (Procardia®): Use of melatonin and nifedipine at the same time has resulted in elevations in blood pressure and heart rate.
    • fluvoxamine (Luvox®): Fluvoxamine may increase blood levels of melatonin, resulting in sedation.
    • blood thinners such as warfarin: Caution is warranted, as a single dose of melatonin was found to decrease clotting factors in the lab tests of healthy adults. Therefore, it may increase the chance of adverse effects when used with blood-thinning drugs.
    • Rhubarb: A study using human primary hepatocytes showed that concomitant use can cause metabolic disorder of melatonin.
    Melatonin & Aging https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12525
    Melatonin inhibited a fluoride‐induced upregulation of NADPH oxidase, iNOS expression, the phosphorylation of c‐Jun N‐terminal kinase (JNK) and reduced the release of TNFα and IL‐1β.

    upload_2020-11-22_15-14-57.png

    Melatonin & Energy Metabolism - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200827/
    Melatonin regulates epigenetic processes in neuronal cells. These neuronal cells are influenced by energy metabolism. The anti-aging properties of melatonin regulate energy metabolism, leading to longevity.
     
    Last edited: Nov 22, 2020
    JanSz likes this.
  17. Sue-UK

    Sue-UK Gold

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409706/
    Dietary Sources and Bioactivities of Melatonin

    "In human beings, as the endogenous melatonin alters all through the life, the dietary intake might partially recompense the declined endogenous melatonin after puberty."

    If it occurs naturally in a food, even with a low intake and a short half life, regular consumption could be a "pre-treatment" similar to this study

    https://pubmed.ncbi.nlm.nih.gov/25904702/
    Melatonin pretreatment of human adipose tissue-derived mesenchymal stromal cells enhances their prosurvival and protective effects on human kidney cells
     
  18. Sue-UK

    Sue-UK Gold

    Breast cancer as a excessive fission process or fusion/fission imbalance:

    "In the same way that fission allows for redistribution of mitochondria in dividing cells, fission allows breast cancer cells to spread and metastisize (invade tissue and organs) more easily. Fission allows for the redistribution of mitochondria to the leading edge of metastisizing breast cancer cells, causing greater energy production at those sites, and thus driving more rapid tumour growth. It is highly likely that excessive mitochondrial fission will be found to be related to other cancers as further studies are carried out." (Source book Mitochondria in Health and Disease by Ray Griffiths).

    Mitochondrial fusion with stearic acid:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946230/
    Stearate Preferentially Induces Apoptosis in Human Breast Cancer Cells
     
    John Schumacher likes this.
  19. JanSz

    JanSz Gold

    John, thank you for your comments.
    Highly appreciated.
    If all goes as planned my next big testing should happen sometime in the middle of January 2021.
    That should include
    LabCorp.com
    Spectracell.com
    DUTCHtest.com
    ==============================


    [QU OTE="John Schumacher, post: 293458, member: 23768"]When supplementing with melatonin, please consider:
    I would titrate up, starting with
    one dose at 3pm, second after "dinner" (I eat before sunset) and a third before bed.
    Note: we will need to look at any contraindications with a dose of 9mg to 12mg per day.


    So far clinical studies come in for melatonin dosages at:
    General contraindications:
    • nifedipine (Procardia®): Use of melatonin and nifedipine at the same time has resulted in elevations in blood pressure and heart rate.
    • fluvoxamine (Luvox®): Fluvoxamine may increase blood levels of melatonin, resulting in sedation.
    • blood thinners such as warfarin: Caution is warranted, as a single dose of melatonin was found to decrease clotting factors in the lab tests of healthy adults. Therefore, it may increase the chance of adverse effects when used with blood-thinning drugs.
    • Rhubarb: A study using human primary hepatocytes showed that concomitant use can cause metabolic disorder of melatonin.
    Melatonin & Aging https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12525
    Melatonin inhibited a fluoride‐induced upregulation of NADPH oxidase, iNOS expression, the phosphorylation of c‐Jun N‐terminal kinase (JNK) and reduced the release of TNFα and IL‐1β.

    View attachment 17056

    Melatonin & Energy Metabolism - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200827/
    Melatonin regulates epigenetic processes in neuronal cells. These neuronal cells are influenced by energy metabolism. The anti-aging properties of melatonin regulate energy metabolism, leading to longevity.[/QUOTE]
    ===================================================================
    Since I know the status of my TNFα
    two years ago and it was 9.09% below the middle of the laboratory range,
    do you have anything comments to offer about it?

    Average(0.0, 2.2)=1.1
    upload_2020-11-23_8-32-36.png


    upload_2020-11-23_8-19-55.png
     
    Last edited: Nov 23, 2020

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