That this is even an issue has got my dander up: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286826/.

Saying the 'the elderly' are at risk for this, and 'the elderly' are at risk for that is pure intellectual laziness. We make poor lifestyle choices, they simply add up over time ... and, voila!, so-called age-related diseases manifest. It's just high-order BS.

Generally we older folks on this forum already know enough about the road to optimal to realize how shallow conventional wisdom is. We've discovered some great workarounds for health issues we are facing. One of the best strategies is taking advantage of the Ancient Pathway via CTing to reverse biological age. Backed by telomere biohacking. That's one of the most exciting reveals from @Jack Kruse that I can think of, among many others.

I'd like this thread to attract some participants like @JanSz and @John Schumacher who are also traveling this 'aging' path and have some informative experiences to share and exchange. Calling attention to Jack's nuggets is almost a full-time job, and worth every effort. Talking about what we find, how we apply it, and how it works for us could be immeasurably invaluable.

One of my biggest concerns, for example, is my insurance coverage. It's completely through Medicare, without extras for hearing, eyes, or dental. It's bad enough that Medicare is severely limited on what it will cover. It's also a political football to be kicked around by the powers that be without regard to consequences to real people.

In the face of that, my greatest security is what I've learned about being truly healthy acc. to the Epi-Paleo Rx. This is more empowering than I ever knew possible. My health is my responsibility, not the government's.

Yeah, it's not all shits and giggles. I've had quite a few successes, and a few failures. Sharing my experiences will ideally help others. And vice versa.

 

females [older] allowed??????

 

@caroline @Sue-UK @Dennis Clark @JanSz -> Ladies & gentlemen, I would like to present for your review:

Impaired peroxisomal and mitochondrial respiration and phospholipid instability

In the last two decades more is “understood” about the role of peroxisomal impairment in all neurological disease states – AD, Autism, ADHD, ALS and just “getting old”. In this review of the literature, I will walk us through:

· The Peroxisome-Mitochondria Connection - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292478
· Mitochondrial Dynamics in the metabolic signaling pathways - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292479
· The Lipid Transport interfaces - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292480

• Beta Oxidation occurs in our mitochondria
• Alpha & Beta Oxidation occurs in our peroxisome
  
• Omega Oxidation occurs in our endoplasmic reticulum

· Fatty acid β-oxidation metabolism between the peroxisome & mitochondria - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292481
· Cellular Signaling involved in Lipid Metabolism - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292482
· Peroxisomal plasmalogen synthesis - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292483
· Thermogenesis in mitochondrial fission - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292484
· Cholesterol Trafficking - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292485
· Peroxisomal matrix enzymes – How their deficiencies could be mitigated and a partial set of interventions - https://forum.jackkruse.com/index.php?threads/granpa-johns-optimal-journal.23952/page-4#post-292486

What is missing is not just a limited “primitive identification” of molecular profile and fatty acid metabolism but what potentiates healthier cellular fatty acid synthesis and what stimuli it requires.

Looking Forward...
John

 

Hope you get all that Caroline as I certainly don't!

 

https://www.researchgate.net/publication/287631429_Peroxisomes_Organization_and_Transport_in_Neurons
Peroxisomes: Organization and Transport in Neurons

 

Yes, you will.
Just wait for the part of the practical applications (for most of identified shortcomings).
That is the sole purpose of this thread.
Do I get a yes from @John Schumacher and @Dennis Clark ???????

///////////
As of now, what Patricia Kane and her husband (Ed Kane) were able to accomplish is largely in
http://www.bodybio-wellness.com
bodybio.com
and her DETOXX book

https://patriciakane.net/

www.milz-bieber.de

BodyBio-wellness.com

BodyBio PC Bulletin

Balance Oil Bulletin

BodyBio.com



....

 

@Sue-UK -> Did you read the referenced article you posted?
It is included in my write up for your review.

There are two things to understand about peroxisomes inside neurons: structure and process

What is the molecular composition of optimal peroxisomes?
"Currently", our description/identification of its composition is NOT optimal. When reviewing the sources of the biopsies used in analysis, its not from healthy animals. The data surrounding the "feed" to the animal(s) is not understood - from the perspective that it "influences" the composition of the peroxisome. Our data points are still very primitive. Thus when the molecular composition of a peroxisome is "identified", we must think "beyond the box".

For example the following is our "current" view point at this data set:
The peroxisomal membrane contains the major cellular phospholipids—phosphatidylcholine (48.2%), phosphatidylethanolamine (22.9%), and phosphatidylinositol (15.8%)—but also has a remarkably high cardiolipin content (7%).

Our "current" depiction of cardiolipin is :
Cardiolipin contains almost exclusively 18 carbon fatty acids, and 80% of this is typically linoleic acid (18:2(n-6))

So, even with our current understanding, peroxisomes are a combination of glycerol esterified with two fatty acids and phosphoric acid.
My "contention" is the molecular makeup of the two fatty acids. The question is -> what fatty acids are optimal for human phospholipid bilayers?

To the "best" of current hypothesis -> The amounts of DHA, AA and LA decreased almost 20-, 5- and 0.3-fold, respectively. The energies for H-abstraction in α-position to bis-allylic double-bonds for different FA with multiple double bonds decrease in the order LA<AA<DHA. Accordingly, the propagation rate constants for FA oxidation determined for LA (one bis-allylic group), AA (3 bis-allylic groups), EPA (4 bis-allylic groups) and DHA (5 bis-allylic groups) increase at ratios of 1, 3.2, 4.0, and 5.4.

How peroxisomes play in the game of neuron cells?
We currently have identified the following:

Peroxisomes’ role in amino acid metabolism notably the D-amino acids. Two different degradative enzymes D-amino acid oxidase (DAO) and D-aspartate oxidase (DDO). DAO and DDO are presumed to regulate the levels of several endogenous and exogenous D-amino acids including D-serine and D-aspartate in various organs notably the brain. D-serine for instance binds to the glycine binding site of the N-methyl-D-aspartate (NMDA) receptor and potentiates glutamatergic neurotransmission in the central nervous system. Several lines of evidence suggest that D-serine plays an important role inthe regulation of brain functions by acting as co-agonist for the NMDA receptor and perturbations in D-serine in the nervous system have recently been implicated in the pathophysiology of various neuropsychiatric disorders. Recent studies have shown that D-aspartate acts as signaling molecule in nervous and neuroendocrine systems at least in part by binding to the NMDA receptor and, thus plays an important role in the regulation of brain function.

Peroxisome also plays a major role in cellular ROS/RNS-metabolism. Indeed, peroxisomes contain a large number of ROS-producing enzymes of which the acyl-CoA oxidases are the most abundant being present in virtually all peroxisomes independent of the tissue and cell type involved. Other H2O2 producing oxidases include D-amino acid oxidase (DAO), D-aspartate oxidase (DDO), L-pipecolate oxidase (PIPOX), 2-hydroxy acid oxidases (HAO), polyamine oxidase, and xanthine oxidase.

Looking Forward...
John

Note to @JanSz - Please take a moment to read "Impaired peroxisomal and mitochondrial respiration and phospholipid instability" as well as this response to @Sue-UK -> It contains my response to your interest in bodybio and their products.

 

Patricia Kane answered that question by:
Analyzing patient's Fatty Acids at Krieger's using her list (Only part of those are analyzed in Mayo Clinic (which is what I did using):
Fatty Acid Profile, Comprehensive (C8-C26), Serum
Assuming that each analyzed fatty acid should place itself within (plus or minus) 25% of the middle of its laboratory expected range.
She calls it %Status
In summary, they are divided into three categories:
Burn it
Build it
Balance it

Pictures below can be better viewed here:
http://www.bodybio-wellness.com/report-fatty-acid.html

 

When supplementing, BodyBio puts emphasis on:
1.BodyBio PC which contains:
Phosphatidylcholine (PC) - essential for memory*
Phosphatidylethanolamine (PE) - vital to mitochondrial function*
Phosphatidylinositol (PI) - supportive to the brain and neurotransmission*

2.Balance Oil (LA & ALA in 4:1 ratio)

3. Variety of Butyrate (C4:0) fatty acid mises with (sodium, potassium, calcium or magnesium)

.......................
NOTE
But BodyBio when using PC (PC + PE + PI) claims are about improving mitochondrial membranes.
I have newer seen them mentioning peroxisome membranes.

Note absence of phosphatidylserine (PS)

 

https://en.wikipedia.org/wiki/Phosphatidylserine

 

So, even with our current understanding, peroxisomes are a combination of glycerol esterified with two fatty acids and phosphoric acid.
My "contention" is the molecular makeup of the two fatty acids. The question is -> what fatty acids are optimal for human phospholipid bilayers? "

Those analyses were in "Impaired peroxisomal and mitochondrial respiration and phospholipid instability"
This is why we have these problems.

It is no surprise that LA (one bis-allylic group), AA (3 bis-allylic groups) are very vulnerable to all ROS events including fatty acid metabolism. If you need, we can walk through these processes.

However, the question one should ask is why would Dr Patricia Kane prescribe these fats?
The answer is in her interpretation of research, for example: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509651/ - Even though it was made clean in the article that "The increased presence of 22:6 in the cardiac and skeletal muscle membrane has been linked with improved oxygen efficiency of muscular contractions and fatigue resistance."

So back to the question - why would Dr Patricia Kane prescribe these fats?
Because she believes "Fish oil displaces linoleic in mitochondria via cardiolipin"

Why would she believe this? -> because of her clinical experience working the Autism patients.

What do we know about Autism?
I began working Autism clients 44 years ago. They are a interesting group having specific set biological dysfunctions and behavioral issues; most onsets of Autism are similar occurring as early as two years of age.

When working with Autism -> There are two questions a clinician needs to ask: Do these symptoms (including behavior) indicate an acute or chronic decease state?

• According to the doctors at bodybio, the decease state is acute requiring immediate intervention for which we can agree. This may mean a prescription of interventions specific for the diagnose which may not transcend to the public in general. Specially, the displacement of lipid 18:2 from the cardiolipin. They found when they displaced 18:2, the patient did not improve.

The question should be - do we know why? The answer is as simple as too much change too fast.

Autism is multifaceted biologically and behaviorally. Many doctors over the years have had great success including Dr. Natasha Campbell-McBride MD.
As a clinician, one must take into account why the client exhibits dysfunction in: digestion (IBS), gross motor control, neurological processing, speech, including what precipitates emotional dysfunction.

Typically we know Autism patients have parasites, mold toxicity as well as the beginning of neurological network dysfunction <- My purpose here is not to argue a diagnosis. There are many, many, many more vulnerabilities the Autism patient has including vaccines. However, there are thousands of PEER articles on the "subject".

When treating Autism from a biological point of view rather than behaviorally, we must evaluate the most critical acute set of symptoms first.
As you know, since I'm on this Blog, I believe that the voltage (light-water-magnetism) needs to be addressed. How that is addressed is very involved and requires complete compliance by the care-provider (parent), patient and patient family.

Looking Forward,
John

 

To make things easier.
Assume a 100% healthy person who's the only problem is that hi is getting older.
Assume that he is looking for ways to slow down aging.
No need to assume and discuss autism or any other Dx.

.......
............

 

Thank you !

 

Aging is Not a Disease, Damn It!

How to slow it down?

..........

 

@Dennis Clark @caroline @JanSz -> So let's get back to aging -> What is aging; is it the survival of the leftovers; after we're done with procreation; dried up ovaries; dysfunctional testicles; the Buddhist accumulation of pain with a hope for a nirvana end of our suffering?

Dr Jack Kruse believes in an evolutionary approach, expressed in his book "Epi-Paleo RX" and set as corner-stones of his thoughts throughout his Blog. He believes it has given him predictive ideas about how things (human biology) works. From this belief, he has laid out a nutrient "plan", a therapeutic sunlight "plan", a nnEMF mitigation "plan", a blue-light mitigation "plan", movement (exercise) out in nature "plan", even though rest and recovery are important - he hasn't laid out a "plan" for it that I have seen -> yet.

This is why Dr Jack Kruse recommends: The basic nutritional building blocks starting with fatty acids, specifically DHA; every human cell requires it. When it is sparse, we loss cognitive function as well our sex drive. Proteins also require DHA for its phospholipid bilayer membrane; thus cold water “sea food”. Minerals are used with fatty acids and proteins to build every human cell; thus Dr. Jack Kruse recommends oysters. Enzymes are required in most molecular transformation; these are by plants; thus "sea weed". Nutrition void of these basic building blocks causes the human organism to “create” an alternative pathway (or rewiring) for building these essential elements; this leads to dysfunction.

I am a "non-believing uncircumcised gentile". I believe in the process of identifying “the mechanism of action” to be a reliable scientific method to objectively validate, dispute or reject a hypothesis. Using this discovery process, protocols can be designed, developed, measured, modified and implemented. This may not be as predictive nor as simple as an evolutionary believe system; but it can substantiated.

I see life as a collaborative functional design. It is written into every molecule and atom in our universe. Like, (Dr Rupert Sheldrake PhD Biologist -> from his work demonstrated in hundreds of blind and double-blind scientific experiences plants, animals, etc. he has hypothesized there maybe morphic resonance), I have found the seperated-evolutionary-competive-advantage paradigm to be lacking in evidence despite its strongly held dogma.

So, when we look for solutions to the problem of aging, my attention will be on evidence.

Looking Forward...
John

 

Hi, Caroline...Of course! No limits on who participates. Just looking for what nuggets people have discovered from Jack and how they worked. Thanks for asking, young lady!

Cheers,
Dennis

 

You guys are brilliant .....I will definitely follow along but nuggets from me might be few and far between

I fully and totally subscribe to what Jack told me years ago ....."you don't need to speak Chinese to eat Chinese food"

Science definitely isn't my strong suit but I have always followed the protocols with great success.

You guys impress the heck out of me with your knowledge and commitment and desire to live your most optimal life.

 

I will keep trying Jenny!

 

The third thing is the energy to maintain/repair/improve etc the structure and process.

According to Herrero in the book The Human Photosynthesis, the cell nucleus, Golgi complex and the endoplasmic reticulum (smooth and rough) are "powered" by melanin found in their structures. Then there's neuromelanins, eumelanins etc.

https://forum.jackkruse.com/index.php?threads/melanin-and-quantum-biology.16627/

In the Somlyai book about deuterium and cancer, Defeating Cancer! the mention of Aspergillus niger (p48) ."which in a heavy water medium turns alabaster white which means that the fungus is unable to produce the pigment responsible for the black color."

To me that doesn't mean deuterium is "bad", as in the Dennis Crouse blue zone book, all the blue zones are eating high deuterium diets, but they are also on silica rich diets, and OSA rich water. He also says that normally neuromelanin slowly increases in concentration in neurons of the SN region of the brain from birth to age 90 plus. (The accumulating wisdom of age? Work smarter, not harder. ) But (apart from say dialysis patients), anyone with a damaged BBB and all people over 77 absorb and accumulate more aluminium than normal. A PD patient has 50% less NM. So for me it appears that aluminium accumulation accelerates aging. By weakening the BBB, nnemf/5G etc could be a causal factor, by allowing even pretty low intake access to the brain, interrupting neuromelanin synthesis. Under drinking water could be another causal factor, it could make a TBI or even a less traumatic fall more damaging at a time the BBB is acutely or chronically weakened...(My mother's AD accelerated after a fall where she hit her head). The olfactory bulb has no BBB so any chronic exposure to aluminium via that route could be a causal factor to accelerated aging by aluminium.....