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A Few Questions on PPP and fat

Discussion in 'Beginners Area' started by QiGuy1997, Dec 2, 2013.

  1. Norway-hey

    Norway-hey New Member

    Thanks Cpt. Tired, and I am sorry to hear you had such a bad experience. 150mg of it is a lot. I thought 70mg Vyvanse was the max dosage. Personally dex works like a charm in terms of what I expect from it. Making me driven on doing certain tasks, and enhancing learning and retention. Absolutely no cravings to take it at all, but it makes life easier. Did you ever try doing CT while on the vyvanse? If so did you notice anything weird? I did a couple of times on dex and noticed becoming very calm, which was reflected by my pulse that was lower than usual in those circumstanses. Well, usually dex makes the heart rate go up, so having it go down in and by it self was kind of weird.
    Cpt.Tired likes this.
  2. Cpt.Tired

    Cpt.Tired New Member

    Yeah I did feel quite calm doing CT. Glad that the Dex is working for you. what dose are you taking? 150 mg is definitely way too much but that was the only way I could get it to last. I would spread it out throught the day. It was a gong show. But at times I would get the effect that you have. Never consistently and predictively.
  3. Norway-hey

    Norway-hey New Member

    Cpt. Tired, I take 3x10mg with another 5mg optional if I feel like I need it as a booster towards the end of the day. So 35mg/day at most. Have you looked into the pH of your urine? Sorry for the weird question, but as excretion of amphetamines is dependent on urinary pH, it could be that yours is very low. There are studies on its half life varying between 8 and 31 hours depending on urinary pH. I know I have to be careful of what I eat and take as supps as It may affect the medicine greatly. I.e. I can take something acidifying, like Vitamin C as ascorbic acid in the evening to lower pH and excrete more of the dex, and vice versa, if needed. The point I was really getting at, before burrowing myself too much in the details, was that perhaps you should check your urinary pH if you have not already!? I know I´ve had problems with my medicine working way shorter than normal (2hours instead of 4-6hours) which I believe was due to having very low urinary pH - which was in turn was caused by an underlying acidosis. Hopefully nothing, and definitely a long shot, but perhaps worth looking into? At least pH paper is cheap as chips! Just wanted to let you know!
    Cpt.Tired likes this.
  4. Cpt.Tired

    Cpt.Tired New Member

    Thanks for the heads up on the pH thing. That is something that I have not looked into and makes perfect sense. It's good to have someone else on this site taking the same stuff as I am/was so we can compare notes. How long have you been taking it?
    For me, when I first started taking it about 4-5 years go it was amazing!! I got so much shit done,..stuff that I would not have dreamed that I would ever do without it.. like fix the roof on my house. But then after a while the results became more and more inconsistent. And the MIGRAINES!! Oh my god! Horrible headaches from it.

    When that medication works it is AMAZING but right now though I definitely need a break from it because my blood pressure has gone ridiculously high and it seems to be working against me.
  5. Cpt.Tired

    Cpt.Tired New Member

    Apparently Vyvanse is not affected by pH but who knows? My doc's clinical experience kind of doubts that.
  6. Norway-hey

    Norway-hey New Member

    He is quite right in that absorption of vyvanse is not dependent on pH, unlike dexamphetamine sulphate. But, as Vyvanse is a prodrug of dexamphetamine (Lisdexamphetamine is the aminoacid lysine attached to dexamphetamine) the lysine has to be removed for the medicine to become biologically active. This, as I remember it,happens in the bloodstream and is supposedly rate limited by some enzyme in our red blood cells. But, as the lysine molecule is cleaved off, the active medicine is the same as what I use - dexamphetamine, and its´ excretion thus have to be dependent on the same factors. "ALTHOUGH SEVERAL PATHWAYS, INCLUDING P-HYDROXYLATION, N-DEMETHYLATION, DEAMINATION, & CONJUGATION IN THE LIVER, TAKE PART IN THEIR DISPOSAL, A SUBSTANTIAL FRACTION OF THESE DRUGS /NONCATECHOLAMINES/ IS EXCRETED IN THE URINE UNCHANGED. URINARY EXCRETION OF AMPHETAMINE & MANY OTHER NONCATECHOLAMINES IS GREATLY INFLUENCED BY URINARY PH. FOR EXAMPLE, PKA OF AMPHETAMINE IS 9.9, & AT PH 8.0 ONLY 2-3% IS EXCRETED. IF THE URINE IS ACIDIC, URINARY EXCRETION MAY BE AS MUCH AS 80%.
    Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 166" https://pubchem.ncbi.nlm.nih.gov/compound/amphetamine#section=Absorption-Distribution-and-Excretion I know I´ve seen it in several different papers, but this is the first relevant reference on the matter that I found. Of course, your issues might be something else entirely! It might be tolerance, it might be something completely different. Still, just wanted to give you a heads up and let you be the judge for yourself!
  7. Cpt.Tired

    Cpt.Tired New Member

    Thanks Norway-hey, much appreciated.
    The vyvanse for me seems to work as a pretty decent antidepressant, even when it is not really working as it should. For instance, I can have a wicked migraine that is caused by it and I could be in total pain but at the same time I'm not depressed. Having a chronic low grade depression just eats away at you over time. At least with vyvanse I would have some moments of drive and excitement. Protein is so important with that med. So is hydration.
  8. Mike David

    Mike David Same name new person

    Got it!

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