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5/30 News: Circadian clocks: Body parts respond to day and night independently from brain

Discussion in 'Educating Doctors' started by DrEttinger, May 31, 2019.

  1. DrEttinger

    DrEttinger Choice, the only thing we control

    Hot Off The Presses Yesterday - For my Circadian Rhythm Loving Friends - Okay, we have a master clock, organ clocks, and cell clocks. They can work independently or best, as a group. Fuck with your light and you fuck with your clocks. Artificial Light At Night (ALAN) is the worst offender. Takeaway: your environment controls your physiology to a greater degree than what you put into your body. I'll take a Taco Bell eating surfer's health over an organic food eating New York stockbroker's health any day of the week. Have you ever felt a trillion electron fairies dancing across your cytochromes, via CoQ10, to make ATP, I have.

    Circadian clocks: Body parts respond to day and night independently from brain, studies show
    Date: May 30, 2019
    Source: University of California - Irvine
    Summary: Researchers have suspected that the body's various circadian clocks can operate independently from the central clock in the hypothalamus of the brain. Now, they have found a way to test that theory.

    Can your liver sense when you're staring at a television screen or cellphone late at night? Apparently so, and when such activity is detected, the organ can throw your circadian rhythms out of whack, leaving you more susceptible to health problems.

    That's one of the takeaways from two new studies by University of California, Irvine scientists working in collaboration with the Institute for Research in Biomedicine in Barcelona, Spain.

    The studies, published today in the journal Cell, used specially bred mice to analyze the network of internal clocks that regulate metabolism. Although researchers had suspected that the body's various circadian clocks could operate independently from the central clock in the hypothalamus of the brain, there was previously no way to test the theory, said Paolo Sassone-Corsi, director of UCI's Center for Epigenetics and Metabolism and senior author of one of the studies.

    To overcome that obstacle, scientists figured out how to disable the entire circadian system of the mice, then jump-start individual clocks. For the experiments reported in the Cell papers, they activated clocks inside the liver or skin.

    "The results were quite surprising," said Sassone-Corsi, Donald Bren Professor of Biological Chemistry. "No one realized that the liver or skin could be so directly affected by light."

    For example, despite the shutdown of all other body clocks, including the central brain clock, the liver knew what time it was, responded to light changes as day shifted to night and maintained critical functions, such as preparing to digest food at mealtime and converting glucose to energy.

    Somehow, the liver's circadian clock was able to detect light, presumably via signals from other organs. Only when the mice were subjected to constant darkness did the liver's clock stop functioning.

    In upcoming studies, UCI and Barcelona researchers will phase in other internal clocks to see how different organs communicate with each other, Sassone-Corsi said.

    "The future implications of our findings are vast," he noted. "With these mice, we can now begin deciphering the metabolic pathways that control our circadian rhythms, aging processes and general well-being."

    In earlier studies, Sassone-Corsi has examined how circadian clocks can be rewired by such factors as sleep deprivation, diet and exercise. Exposure to computer, television or cellphone light just before bed can also scramble internal clocks.

    Because of modern lifestyles, it's easy for people's circadian systems to get confused, he said. In turn, that can lead to depression, allergies, premature aging, cancer and other health problems. Further mice experiments could uncover ways to make human internal clocks "less misaligned," Sassone-Corsi added.

    Other UCI researchers involved in the studies included Kevin B. Koronowski, Jacob G. Smith, Muntaha Samad, Siwei Chen, Christophe N. Magnan and Pierre Baldi. The work was supported by the National Institutes of Health, the Novo Nordisk Foundation, the Defense Advanced Research Projects Agency, Spain's Ministry of Economy and Competitiveness, the European Research Council and the government of Catalonia, among other funding sources.
  2. drezy

    drezy New Member

    Morning wood... finally explained.
    DrEttinger likes this.
  3. JanSz

    JanSz Gold

    Kevin B. Koronowski, Jacob G. Smith, Muntaha Samad, Siwei Chen, Christophe N. Magnan and Pierre Baldi.
    not reading @Jack Kruse blog.
    If they did, it would save them time to do something new.
    He is talking abut this for the last 10 or more years.

    Anne V, DrEttinger and drezy like this.
  4. DrEttinger

    DrEttinger Choice, the only thing we control

    Yes, Jack was correct, 'BUT' he knew what he knew based on these same research studies. Without these researchers, Jack, as with us all, would merely be speculating based on observation and previous research. I value every study I have the privilege of being able to read.

    Jack has an advantage over most he teaches. He is able to more quickly, based on his intellect and knowledge base, interpret data and put multiple data sets into the context of the human as a whole. By using himself and others as lab mice he can glean even more data to add to the overall picture.

    This is why I follow Jack. I let him do a lot of the heavy lifting. I take what he has posted, I do my own cross-checking and study and come up with an agreed conclusion or one of my own.
    Ed Pomicter, JanSz and Jude like this.
  5. Sue-UK

    Sue-UK New Member

    Something interesting from Becker's book Cross Currents is a discussion on the earth's rotation through the magnetosphere, and that any given spot on the earth's surface is in a constantly changing magnetic field. There's a diagram of the daily rise and fall in the strength of the magnetic field at one spot on the earth during a quiet period of solar activity. There's also a discussion on what is the magnetic organ, (separate from the pineal), but on the pineal, after acknowledging the retinal pathway, he says (my highlighting)

    ""More recently, it has been shown that the pineal is also sensitive to the daily cyclic pattern in the Earth's magnetic field. Melatonin secretion in human subjects may be changed at will by exposure to steady magnetic fields of the same strength as the geomagnetic field. Apparently, nature determined that biological cycle activity was too important to be left to one environmental signal alone. "

    He also says

    "Nature intended the pineal to simultaneously receive the same signals from the daily pattern of day-night and the same rise and fall in strength of the geomagnetic field. Obviously when one or both signals are abnormal, the pineal does not respond in the normal fashion, and the body's biological cycles become disturbed - with important clinical consequences."

    If light is the dominant signal during the day, and the magnetic field at night, for a nocturnal animal's liver clocks to stop functioning at all in constant darkness, I'd be interested to know if the results were affected by disrupting how they sensed the geomagnetic field, or if the experiment itself had shielded them from it. :)
    Anne V, Paleodocteur, Jude and 3 others like this.
  6. elizabeth north

    elizabeth north New Member

  7. JanSz

    JanSz Gold

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