The last few mornings, when I wake up and stretch a bit in bed before getting up, I have experienced some muscle cramping in foot and calf. It's a mild version of what we called a "charley horse" when I was a kid. It lasts just a few seconds (thank goodness!) and I haven't yet had to jump out of bed to put weight on my foot to release it. I've been introducing the Mito Rx over the past 5 weeks, adding one supplement at a time. I started with Magnesium Malate, then added D-ribose, then Ubiquinol and finally, a little over a week ago, Acetyl-l-Carnitine. I had already been using Mag Oil 2x per day since last summer. I'm wondering if the leg muscle cramping might be a sign that I need to try to up the Magnesium? Or maybe it's a sign of dehydration? I'm also experiencing most mornings in the past week or so some mild headache on rising that clears after a glass of spring water. I am drinking so much more water than before, but perhaps my body is really dehydrated? Anyone else experience this?