Started cycloset and metformin one week ago today and I thought I would share my experience so far. First, I am a long time low carber and have been mostly paleo for a year. My FBG has been rising slowly over the last several years but when I asked my PCP about it she said don't worry, because my HbA1c was "good" at 5.5 % or a little less. Of course that was totally due to diet...hard to have blood sugar spikes if you are eating 40 g or less of carb per day. So, recently my FBG has been topping 120 (120-125), but my post prandial (after a meal) is never higher than 130. On the other hand, it never drops below 105 either. Much of the problem may be connected to sleep apnea, which I've had for years. Apparently it disorders glucose metabolism independent of body weight. So after telling my PCP that it was time to treat this and bringing her references on cycloset and giving her a short version of Jack's ideas about circadian cycles, the epi-paleo diet and hormone balancing, she agreed that cycloset and metformin would be a reasonable next step. To make this a bit shorter, my FBG is down to around 100-103 after a week. Good so far, but I have to say this has not been easy. The downside for me is a bad tummy and baaaad sleep. I am finding most foods nauseating and seafood particularly so, so eating according to the leptin rx and epi-paleo has been a real challenge! Ok. My sleep was really getting better after the leptin rx and working on dhea and CT and I was having nights where I got 8 whole, entire hours! Wow, it makes a difference. However, after I started the cycloset and metformin, bang! Bad sleep again. I have gone to bed by 10:30 the last 6 nights and every night like clockwork, I wake up at 2:30 am. The worst part is that I am not able to get back to sleep at all. So, 4 hours per night for the last 6 nights. I am really exhausted and I am hoping this cycle will end soon (to be honest it was a bit better last night, I slept a bit over 5 hours). Even though I have cut back quite a bit on the amount I was eating due to the nausea, I'm still trying to follow the guidelines as closely as I can. I'm also making sure I get at least two servings of fermented veggies per day, hoping that it will settle my stomach a bit. I am sure other people will react differently than me. I just thought there might be some value in letting people know what my experience with these drugs has been so far. I'm hanging in there and will post again when things change.